Supercritical solvent impregnation of mango leaves extract in wound dressings

Resumen

Usually, the impregnation of active agents into polymeric matrices has been carried outeither during the synthesis or processing of polymers or by immersion and soaking of thepolymeric materials in a solution containing the bioactive substances. These processescan lead to unwanted reactions between substances, thermal degradation of some of themand also involve the use of toxic organic solvents that must be removed from the matrices.Supercritical solvent impregnation (SSI), a more efficient and environmentally friendlytechnique solves some of those problems. The solvating capacity of the CO2 as carrierand its high diffusivity favour an easier and faster penetration of the active agent throughthe matrix [1]. The impregnation of active molecules occurs as a consequence of theinteraction balance between the active substance, the matrix and the supercritical phase,which results in an adsorption or a physicochemical attachment of molecules to thematrix.