Estudio de la prevalencia de los polimorfismos comunes del gen del receptor de estrógenos (ESRα) y su relación con la densidad mineral ósea en mujeres españolas postmenopáusicas

Abstract

Osteoporosis is a common metabolic disorder worldwide. The prevalence of osteoporosis is high in postmenopausal women. The estrogen deficit is an important risk factors for osteoporosis and is associated with the osteoporosis postmenopausal. Many genes have been identified that might be involved in the disorder, including the estrogen receptor alpha (ESRa) gene, with contradictory results. The prevalence of osteoporosis is high in Spain and in Extremadura. However, only a few studies have been conducted in the Spanish population and hence, worldwide results do not necessarily may be extrapolated to these population, as they come from very different ethnic samples with diverse environmental situations. The present study is aimed at investigating the role of ESRa gene polymorphisms (PvuII y XbaI) and its influence on the presence or absence of osteoporosis in postmenopausal women in Spain. 205 postmenopausal women were included in the study. The genotype distributions of ESRa gene in the present study are in accordance with previous reports in postmenopausal women in Spain. We studied the relationships of PvuII and XbaI polymorphisms of the ESRa gene with speed of sound at the phalanx and with BMD measured at the lumbar spine (L2, L3, L4, L2-L4), femoral neck, trochanter and Ward's triangle. In our study, we have observed no significant relationship. Neither has been found evidence of polymorphism�s associated with increased or decreased osteoporosis risk in the studied sample.