El entrenamiento en memoria de trabajo mejora la eficiencia cognitiva en pacientes de Esclerosis Múltiple

  1. Forn, C 1
  2. BrosetaTorres, R. 2
  3. Miró-Padilla, A 1
  4. Cruz-Gómez, Á. J. 1
  5. Carla Sanchis Segura 1
  1. 1 Universitat Jaume I. Departament de Psicología Básica Clínica i Psicobiololgía
  2. 2 Hospital de la Plana de Vila-real. ERESA, Grupo médico
Journal:
Revista de Discapacidad, Clínica y Neurociencias: (RDCN)

ISSN: 2341-2526

Year of publication: 2018

Volume: 5

Issue: 2

Pages: 16-25

Type: Article

DOI: 10.14198/DCN.2018.5.2.03 DIALNET GOOGLE SCHOLAR lock_openRUA editor

More publications in: Revista de Discapacidad, Clínica y Neurociencias: (RDCN)

Abstract

Multiple Sclerosis (MS) is a disease usually associated with a working memory (WM) impairment. Study the efficacy of a WM cognitive training program in MS patients. 29 relapsing-remitting MS patients were enrolled in the study: 15 underwent WM training and 14 were assigned to a control group. All participants were neuropsychologically assessed and Functional Magnetic Resonance imaging (fMRI) images were acquired during 2 and 3-back execution (baseline and post-training +7days). Training improved MS patients’ performance in 2 and 3-back, hence showing shorter reaction times (RT) and higher percentages of correct responses (p<.001). During 2-back performance, non-trained MS-patients exhibited a greater activation in in right angular gyrus (FWEc=125, p<.001) that was correlated to RT (r=.459, p<.05). Further, lower activation in right precentral gyrus in the trained MS-patients (FWEc=273, p<.01) was also found. The results obtained demonstrates the effectiveness of a WM training program in MS-patients. Trained MS-patients showed a marked improvement of WM performance and increased cognitive efficiency, i.e, using less cerebral resources to achieve higher performance.

Bibliographic References

  • Campbell J, Langdon D, Cercignani M, Rashid W. A Randomised Controlled Trial of Efficacy of Cognitive Rehabilitation in Multiple Sclerosis: A Cognitive, Behavioural, and MRI Study. Neural Plast [Internet]. 2016 [cited 2018 Mar 27];2016:1-9. doi: https://doi.org/10.1155/2016/4292585
  • Chiaravalloti ND, DeLuca J. Cognitive impairment in multiple sclerosis. Lancet Neurol [Internet]. 2008 Dec 1 [cited 2018 Mar 27];7(12):1139-51. doi: https://doi.org/10.1016/S1474-4422(08)70259-X
  • D'Esposito M, Chen AJ-W. Neural mechanisms of prefrontal cortical function: implications for cognitive rehabilitation. Prog Brain Res [Internet]. 2006 [cited 2018 Mar 27];157:123-39. doi: https://doi.org/10.1016/S0079-6123(06)57008-6
  • Dunst B, Benedek M, Jauk E, Bergner S, Koschutnig K, Sommer M, et al. Neural efficiency as a function of task demands. Intelligence [Internet]. 2014 Jan [cited 2018 Apr 5];42(100):22-30. doi: https://doi.org/10.1016/j.intell.2013.09.005
  • Fittipaldi-Márquez MS, Cruz-Gómez ÁJ, Sanchis-Segura C, Belenguer A, Ávila C, Forn C. Exploring Neural Efficiency in Multiple Sclerosis Patients during the Symbol Digit Modalities Test: A Functional Magnetic Resonance Imaging Study. Neurodegener Dis [Internet]. 2017 [cited 2018 Mar 27];17(4-5):199-207. doi: https://doi.org/10.1159/000460252
  • Forn C, Barros-Loscertales A, Escudero J, Benlloch V, Campos S, Antònia Parcet M, et al. Compensatory activations in patients with multiple sclerosis during preserved performance on the auditory N-back task. Hum Brain Mapp [Internet]. 2007 May [cited 2018 Mar 27];28(5):424-30. doi: https://doi.org/10.1002/hbm.20284
  • Jaeggi SM, Buschkuehl M, Jonides J, Perrig WJ. Improving fluid intelligence with training on working memory. [cited 2018 Apr 5]. doi: https://doi.org/10.1073/pnas.0801268105
  • Mitolo M, Venneri A, Wilkinson ID, Sharrack B. Cognitive rehabilitation in multiple sclerosis: A systematic review. J Neurol Sci [Internet]. 2015 Jul 15 [cited 2018 Mar 27];354(1-2):1-9. doi: https://doi.org/10.1016/j.jns.2015.05.004
  • Sanz J, Vazquez C. Fiabilidad, validez y datos normativos del Inventario para la Depresión de Beck. Vol. 10, Psicothema. 1998. 303-318 p.
  • Sepulcre J, Vanotti S, Hernández R, Sandoval G, Cáceres F, Garcea O, et al. Cognitive impairment in patients with multiple sclerosis using the Brief Repeatable Battery-Neuropsychology test. Mult Scler [Internet]. 2006 Apr 2 [cited 2018 Mar 27];12(2):187-95. doi: https://doi.org/10.1191/1352458506ms1258oa
  • Wechsler D. Wechsler Adult Intelligence Scale III. Madrid, Spain: TEA; 2001.
Data source: Dialnet