Infecciones víricas

  1. Galán Sánchez, Fátima
  2. Fernández Gutiérrez del Álamo, Clotilde
  3. Rodríguez Iglesias, Manuel
Journal:
Medicine: Programa de Formación Médica Continuada Acreditado

ISSN: 0304-5412

Year of publication: 2014

Issue Title: Enfermedades infecciosas (I): infecciones víricas, infección por VIH

Series: 11

Issue: 49

Pages: 2885-2892

Type: Article

DOI: 10.1016/S0304-5412(14)70711-5 DIALNET GOOGLE SCHOLAR

More publications in: Medicine: Programa de Formación Médica Continuada Acreditado

Abstract

Viruses cause disease after they break through the natural protective barriers of the body, evade immune control, and either kill cells of an important tissue or trigger a destructive immune and inflammatory response. The outcome of a viral infection is determined by the nature of the virushost interaction and the host's response to the infection. Viral infections can be lytic or persistent (latency, recurrence and / or transformation of the the cell). Immune response is the best treatment, but it often contributes to the pathogenesis of a viral infection. The laboratory methods accomplish the following results: description of virus-induced cytopathologic effects (CPEs) on cells, electron microscopic detection of viral particles, isolation and growth of the virus, detection of viral components (proteins and nucleic acids) and evaluation of the patient's immune response to the virus.

Bibliographic References

  • M. Lecuit, M. Eloit The human virome: new tools and concepts Trends Microbiol, 21 (2013), pp. 510-515
  • J.M. Lund, L. Hsing, T.T. Pham, A.Y. Rudensky Coordination of early protective immunity to viral infection by regulatory T cells Science, 320 (2008), pp. 1220-1224
  • Y. Belkaid, B.T. Rouse Natural regulatory T cells in infectious disease Nat Immunol, 6 (2005), pp. 353-360
  • H.W. Virgin Pathogenesis of viral infection D.M. Knipe, P.M. Howley (Eds.), Fields virology, Lippincott, Williams and Wilkins, Philadelphia (2007), pp. p327-p388
  • A. Wald, J. Zeh, S. Selke, T. Warren, A.J. Ryncarz, R. Ashley Reactivation of genital herpes simplex virus type 2 infection in asymptomatic seropositive persons N Engl J Med, 342 (2000), pp. 844-850
  • Q. Li, P.J. Skinne, S.J. Ha, L. Duan, T.L. Mattila, A. Hage Visualizing antigenspecific and infected cells in situ predicts outcomes in early viral infection Science, 323 (2009), pp. 1726-1729
  • H.W. Virgin, E.J. Wherry, R. Ahmed Redefining chronic viral infection Cell, 138 (2009), pp. 30-50
  • P. Klenerman, A. Hill T cells and viral persistence: lessons from diverse infections Nat Immunol, 6 (2005), pp. 873-879 . D.L. Barber, E.J. Wherry, D. Masopust, B. Zhu, J.P. Allison, A.H. Sharpe Restoring function in exhausted CD8 T cells during chronic viral infection Nature, 439 (2006), pp. 682-687
  • M.S. Forman, A. Valsamakis Specimen collection, transport and processing: Virology J. Versalovic, K.C. Carroll, G. Funke, J.H. Jorgensen, M.L. Landry, D.W. Warnock (Eds.), Manual of clinical microbiology (10a ed), ASM Press, Washingotn DC (2011), pp. p1276-p1288
  • L. Landry, A.M. Caliendo, C.C. Ginnochio, Y.W. Tang, A. Valsamakis Algorithms for detection and identification of viruses J. Versalovic, K.C. Carroll, G. Funke, J.H. Jorgensen, M.L. Landry, D.W. Warnock (Eds.), Manual of clinical microbiology (10a ed), ASM Press, Washington DC (2011), pp. p1297-p1301
Data source: Dialnet