Concordancia entre las ecuaciones «Chronic Kidney Disease Epidemiological Collaboration» y «Modification of Diet in Renal Disease» con la «Berlin Initiative Study» para estimar la función renal en las personas mayores

  1. J. Escribano-Serrano 23
  2. C. Casto-Jarillo 34
  3. E. Berruguilla-Pérez 35
  4. M. González-Borrachero 6
  5. J.D. Santotoribio 7
  6. C. Cañavate-Solano 7
  7. M.M. Calero-Ruiz 13
  8. A. Michán-Doña 38
  1. 1 UGC Laboratorio, Hospital Puerta del Mar, Cádiz, España
  2. 2 Unidad de Gestión Clínica (UGC) San Roque, Grupo de Diabetes SEMERGEN, San Roque, Cádiz, España
  3. 3 Grupo GERVA, Instituto de Investigación e Innovación Biomédica de Cádiz (INiBICA), Cádiz, España
  4. 4 UGC Laboratorio, Hospital La Línea de la Concepción, Cádiz, España
  5. 5 UGC Laboratorio, Hospital Punta Europa, Algeciras Cádiz, España
  6. 6 UGC Laboratorio, Hospital Universitario de Jerez de la Frontera, Cádiz, España
  7. 7 UGC Laboratorio, Hospital de Puerto Real, Cádiz, España
  8. 8 UGC Medicina Interna, Hospital Universitario de Jerez de la Frontera, Universidad de Cádiz, España
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Revista:
Semergen: revista española de medicina de familia

ISSN: 1138-3593

Año de publicación: 2019

Número: 7

Páginas: 441-448

Tipo: Artículo

DOI: 10.1016/J.SEMERG.2019.02.012 DIALNET GOOGLE SCHOLAR

Otras publicaciones en: Semergen: revista española de medicina de familia

Resumen

Objetivo El filtrado glomerular estimado (FGe) se determina de forma cotidiana mediante fórmulas basadas en creatinina, pero su fiabilidad en personas mayores es limitada. El objetivo fue analizar la concordancia entre la ecuación BIS1, específica del anciano, y las habituales CKD-EPI y MDRD-IDMS, en una amplia población mayor de 70 años. Material y métodos Estudio transversal retrospectivo. Se calculó FGe por BIS1, CKD-EPI y MDRD-IDMS a partir de datos de sexo, edad y creatinina en 85.089 personas (58,5% mujeres, mediana edad 78 años [RIC 73-83]). Se realizan: test de Wilcoxon, análisis gráfico de Bland-Altman, estudio de la concordancia con el coeficiente de correlación intraclase y tablas comparativas para la clasificación de ERC. Resultados Las medianas de FGe fueron por BIS1 58 mL/min/1,73m2 (RIC 48-70), por CKD-EPI 68 mL/min/1,73m2 (RIC 53-84) y por MDRD-IDMS 68 mL/min/1,73m2 (RIC 53-82). Se encontró una aceptable concordancia entre BIS1 y CKD-EPI (coeficiente de correlación intraclase = 0,87), menor con MDRD-IDMS (coeficiente de correlación intraclase = 0,81) y una diferencia media de BIS1 vs. CKD-EPI de 8 mL/min/1,73m2 (DE 2,6-18) y de BIS1 vs. MDRD-IDMS de 10 mL/min/1,73m2 (DE 6-27), mantenida al estratificar por sexos y grupos de edad. Conclusiones A pesar del aceptable acuerdo estadístico, el FGe obtenido con la ecuación BIS1 no es intercambiable ni con CKD-EPI ni con MDRD-IDMS. La ecuación BIS1 presenta valores más bajos que CKD-EPI y clasifica en un estadio mayor de ERC a los pacientes, principalmente, cuando FGe está por encima de 30 mL/min/1,73m2.

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Fuente de los datos: Dialnet