Concordancia entre las ecuaciones «Chronic Kidney Disease Epidemiological Collaboration» y «Modification of Diet in Renal Disease» con la «Berlin Initiative Study» para estimar la función renal en las personas mayores

  1. J. Escribano-Serrano 23
  2. C. Casto-Jarillo 34
  3. E. Berruguilla-Pérez 35
  4. M. González-Borrachero 6
  5. J.D. Santotoribio 7
  6. C. Cañavate-Solano 7
  7. M.M. Calero-Ruiz 13
  8. A. Michán-Doña 38
  1. 1 UGC Laboratorio, Hospital Puerta del Mar, Cádiz, España
  2. 2 Unidad de Gestión Clínica (UGC) San Roque, Grupo de Diabetes SEMERGEN, San Roque, Cádiz, España
  3. 3 Grupo GERVA, Instituto de Investigación e Innovación Biomédica de Cádiz (INiBICA), Cádiz, España
  4. 4 UGC Laboratorio, Hospital La Línea de la Concepción, Cádiz, España
  5. 5 UGC Laboratorio, Hospital Punta Europa, Algeciras Cádiz, España
  6. 6 UGC Laboratorio, Hospital Universitario de Jerez de la Frontera, Cádiz, España
  7. 7 UGC Laboratorio, Hospital de Puerto Real, Cádiz, España
  8. 8 UGC Medicina Interna, Hospital Universitario de Jerez de la Frontera, Universidad de Cádiz, España
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Journal:
Semergen: revista española de medicina de familia

ISSN: 1138-3593

Year of publication: 2019

Issue: 7

Pages: 441-448

Type: Article

DOI: 10.1016/J.SEMERG.2019.02.012 DIALNET GOOGLE SCHOLAR

More publications in: Semergen: revista española de medicina de familia

Sustainable development goals

Abstract

Objective Estimated glomerular filtration rate (eGFR) is calculated routinely using creatinine-based formulas, but their reliability in the elderly is limited. The aim of this study was to analyse the concordance between the BIS1 equation which is specific for the elderly, and the usual CKD-EPI and MDRD-IDMS in a large population over 70 years of age. Material and methods Retrospective cross-sectional study in which the eGFR was calculated using BIS1, CKD-EPI and MDRD-IDMS equations based on gender, age, and creatinine data of 85,089 subjects (58.5% women, mean age 78 years [IQR 73-83]).The following statistics were carried out: Wilcoxon test, Bland-Altman graphic analysis, study of the concordance using the intraclass correlation coefficient (ICC), and comparison tables for the classification of CKD. Results The median of the eGFRs using BIS1 was 58 mL/min/1.73m2 (IQR 48-70), using CKD-EPI was 68 mL/min/1.73m2 (IQR 53-84), and using MDRD it was 68 mL/min/1.73m2 (IQR 53-82). The concordance between BIS1 and CKD-EPI (intraclass correlation coefficient = 0.87) was found to be acceptable. It was lower with MDRD (intraclass correlation coefficient = 0.81). A mean difference of 8 mL/min/1.73m2 (SD 2.6-18) was found BIS1 vs. CKD-EPI, and 10 mL/min/1.73m2 (SD 6-27) with BIS1 vs. MDRD, which was maintained when stratifying by gender and age groups. Conclusions Despite the acceptable statistical agreement, the eGFR obtained with the BIS1 equation is not interchangeable with CKD-EPI or with MDRD-IDMS. The BIS1 equation gives lower values than CKD-EPI, and classifies patients into a higher level of CKD, mainly when the eGFR is above 30 mL/min/1.73 m2.

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