L-citrulina y su efecto en deportes de resistencia, una revisión sistemática

  1. Adrián Fernández Hernández 1
  2. Casals-Vázquez, C. 2
  1. 1 Universidad de Murcia
    info

    Universidad de Murcia

    Murcia, España

    ROR https://ror.org/03p3aeb86

  2. 2 Universidad de Cádiz
    info

    Universidad de Cádiz

    Cádiz, España

    ROR https://ror.org/04mxxkb11

Journal:
Journal of sport and health research

ISSN: 1989-6239

Year of publication: 2019

Volume: 11

Issue: 3

Pages: 227-240

Type: Article

More publications in: Journal of sport and health research

Abstract

In the last years, the study of L-Citrulline as a supplement has been gaining interest due to its possible applications over the performance in sports. L-Citrulline is a non-essential aminoacid which can be obtained from vegetable or animal sources. This supplement is a precursor of Nitric Oxide, Arginine and has a principal role in the urea cycle. These factors presuppose that the consume of this ergogenic aid could have positive effects over the sport performance. The purpose of this study was to make a systematic review with which verify the efficacy of L-Citrulline or Citrulline Malate over various determinants parameters over the sport performance and other variables such as perception of effort and physiological factors in endurance sports. To achieve this objective, a research of the existent studies referred to the analysis of the sport performance after the consumption L-Citrulline was made. Finally, 7 studies were obtained and used to make this systematic review. After the analysis of the collected data it can be said that L-Citrulline or Citrulline Malate might have a positive impact over the sport performance. Nevertheless, a consensus must be made in order to achieve the standardization of the protocols and test used in the different studies to say that this supplement has a significant positive impact over the athletes performance.

Bibliographic References

  • Ardle, M.C., & W. D. Katch. (1986). Exercise Physiology. Energy, Nutrition, and Human Performance. Philadelphia: Lea and Feibiger.
  • Bailey, S. J., Blackwell, J. R., Lord, T., Vanhatalo, A., Winyard, P. G., & Jones, A. M. (2015). L-citrulline supplementation improves O2 uptake kinetics and high-intensity exercise performance in humans. Journal of Applied Physiology, (63). Jap.00192.2014. https://doi.org/10.1152/japplphysiol.00192.2014
  • Bailey, S. J., Blackwell, J. R., Williams, E., Vanhatalo, A., Wylie, L. J., Winyard, P. G., & Jones, A. M. (2016). Two weeks of watermelon juice supplementation improves nitric oxide bioavailability but not endurance exercise performance in humans. Nitric Oxide-Biology and Chemistry, 59, 10–20. https://doi.org/10.1016/j.niox.2016.06.008
  • Botchlett, R., Lawler, J. M., & Wu, G. (2013). L-Arginine and L-Citrulline in Sports Nutrition and Health. Nutrition and Enhanced Sports Performance: Muscle Building, Endurance, and Strength. Elsevier Inc. https://doi.org/10.1016/B978-0-12-396454-0.00045-X
  • Cheng, I. S., Wang, Y. W., Chen, I. F., Hsu, G. S., Hsueh, C. F., & Chang, C. K. (2016). The Supplementation of Branched-Chain Amino Acids, Arginine, and Citrulline Improves Endurance Exercise Performance in Two Consecutive Days. Journal of Sports Science and Medicine, 15(3), 509–515.
  • Cunniffe, B., Papageorge, M., O’Brien, B., Grimble, G. K., Davies, N. A., & Cardinale, M. (2014).The Acute Effects of Citrulline-Malate Supplementation on High Intensity Cycling Performance and Muscle Oxygenation. Medicine and Science in Sports and Exercise, 46(5), 132.
  • Cutrufello, P., Gadomski, S. & Zavorsky, G. (2015). The effect of L-Citrulline and watermelon juice supplementation on anaerobic and aerobic exercise performance. Journal of Sports Sciences, 33(14), 1459-1466. https://doi.org/10.1080/02640414.2014.990495.
  • Durlak, J.A. & Lipsey, M.W. (1991). A practitioner's guide to meta-analysis. American Journal of Community Psychology, 19(3), 291- 332.
  • Hartman, W. J., Torre, P. M., & Prior, R. L. (1994). Dietary citrulline but not ornithine counteracts dietary arginine deficiency in rats by increasing splanchnic release of citrulline. The Journal of nutrition, 124(10), 1950-1960.
  • Hickner, R. C., Tanner, C. J., Evans, C. A., Clark, P. D., Haddock, A., Fortune, C., & McCammon, M. (2006). L-citrulline reduces time to exhaustion and insulin response to a graded exercise test. Medicine and Science in Sports and Exercise, 38(4), 660–666. https://doi.org/10.1249/01.mss.0000210197.02576.da
  • Marini, J. C. (2012). Arginine and Ornithine are the main precursors for Citrulline Synthesis in Mice. Journal of Nutrition, 142, 572–580. https://doi.org/10.3945/jn.111.153825
  • Matveev,L. (1985). Fundamentos del entrenamiento deportivo. Madrid: Rubiños Raduga.
  • Pérez-Guisado, J., & Jakeman, P. M. (2010). Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. Journal of Strength and Conditioning Research / National Strength & Conditioning Association, 24(5), 1215–22. https://doi.org/10.1519/JSC.0b013e3181cb28e0
  • Petrovic,V. Buzadzic, B., Korac, A., Vasilijevic, A., Jankovic, A., Micunovic, K. & Korac, B. Antioxidative defence alterations in skeletal muscle during prolonged acclimation to cold: role of L-Arginine/NO-Producing Pathway. Journal of Experimental Biology, 211(1), 114-120.
  • Shamseer, L., Moher, D., Clarke, M., Ghersi, D., Liberati, A., Petticrew, M., … PRISMA-P Group. (2015). Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation. BMJ (Clinical Research Ed.), 349(3), g7647. https://doi.org/10.1136/bmj.g7647
  • Stear, S. J., Castell, L. M., Burke, L. M., Jeacocke, N., Ekblom, B., Shing, C., & Lewis, N. (2010). A-Z of nutritional supplements: dietary supplements, sports nutrition foods and ergogenic aids for health and performance-part 10. British Journal of Sports Medicine, 44(9), 688–690. https://doi.org/10.1136/bjsm.2010.075218
  • Sureda, A., Córdova, A., Ferrer, M. D., Pérez, G., Tur, J. A., & Pons, A. (2010). L-Citrullinemalate influence over branched chain amino acid utilization during exercise. European Journal of Applied Physiology, 110(2), 341–351. https://doi.org/10.1007/s00421-010-1509-4
  • Sureda, A., Cordova, A., Ferrer, M. D., Tauler, P., Perez, G., Tur, J. a, & Pons, A. (2009). Effects of L-citrulline oral supplementation on polymorphonuclear neutrophils oxidative burst and nitric oxide production after exercise. Free Radical Research, 43(9), 828–835. https://doi.org/10.1080/10715760903071664
  • Suzuki, T., Morita, M., Kobayashi, Y., & Kamimura, A. (2016). Oral L-citrulline supplementation enhances cycling time trial performance in healthy trained men: Doubleblind randomized placebo-controlled 2-way crossover study. Journal of the International Society of Sports Nutrition, 13. https://doi.org/10.1186/s12970-016-0117-z
  • Tarazona-Diaz, M. P., Alacid, F., Carrasco, M., Martinez, I., & Aguayo, E. (2013). Watermelon Juice: Potential Functional Drink for Sore Muscle Relief in Athletes. Journal of Agricultural and Food Chemistry, 61(31), 7522– 7528. https://doi.org/10.1021/jf400964r
  • Vanuxem, P., Vanuxem, D., Fomaris, E. & Bernasconi,P. The role of lactate and ammonium in fatigue. Gazette Medicale, 7, 62-72.
  • Williams, M., Lambert, C., Tipton, K., Phillips, S., Williams, M., Lawrence, M., & Wolfe, R. (2005). Dietary Supplements and Sports Performance: Amino Acids. Journal of the International Society of Sports Nutrition, 2(2), 63. https://doi.org/10.1186/1550-2783-2-2-63.