Organoids Models for the Study of Cell-Cell Interactions

  1. Margarita Jimenez-Palomares
  2. Alba Cristobal
  3. Mª Carmen Duran Ruiz
  1. 1 Universidad de Cádiz
    info

    Universidad de Cádiz

    Cádiz, España

    ROR https://ror.org/04mxxkb11

  2. 2 University Medical Center Utrecht
    info

    University Medical Center Utrecht

    Utrecht, Holanda

    ROR https://ror.org/0575yy874

Book:
Cell Interaction - Molecular and Immunological Basis for Disease Management

Publisher: Bhawana Singh

Year of publication: 2021

Type: Book chapter

DOI: 10.5772/INTECHOPEN.94562 GOOGLE SCHOLAR lock_openOpen access editor

Abstract

Organoids have arisen as promising model systems in biomedical research and regenerative medicine due to their potential to reproduce the original tissue architecture and function. In the research field of cell–cell interactions, organoids mimic interactions taking place during organogenesis, including the processes that conduct to multi-lineage differentiation and morphogenetic processes, during immunology response and disease development and expansion. This chapter will address the basis of organoids origin, their importance on immune system cell–cell interactions and the benefits of using them in biomedicine, specifically their potential applications in regenerative medicine and personalized therapy. Organoids might represent a personalized tool for patients to receive earlier diagnoses, risk assessments, and more efficient treatments.