Impact of Relative Muscle Power on Hospitalization and All-Cause Mortality in Older Adults

  1. Losa-Reyna, Jose 123
  2. Alcazar, Julian 12
  3. Carnicero, Jose 134
  4. Alfaro-Acha, Ana 13
  5. Castillo-Gallego, Carmen 13
  6. Rosado-Artalejo, Cristina 13
  7. Rodríguez-Mañas, Leocadio 14
  8. Ara, Ignacio 12
  9. García-García, Francisco José 13
  1. 1 CIBER of Frailty and Healthy Aging (CIBERFES), Madrid, Spain
  2. 2 GENUD Toledo Research Group, Universidad de Castilla-La Mancha, Toledo, Spain
  3. 3 Department of Geriatrics, Hospital Virgen del Valle, Complejo Hospitalario de Toledo, Spain
  4. 4 Department of Geriatrics, Hospital Universitario de Getafe, Spain
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Revista:
The Journals of Gerontology: Series A

ISSN: 1079-5006,  1758-535X

Año de publicación: 2021

Volumen: 77

Número: 4

Páginas: 781-789

Tipo: Artículo

DOI: 10.1093/GERONA/GLAB230 GOOGLE SCHOLAR lock_openAcceso abierto editor

Otras publicaciones en: The Journals of Gerontology: Series A

Resumen

Background: The purpose of this study was to evaluate the relationship of lower-limb muscle power with mortality and hospitalization.Methods: A total of 1 928 participants from the Toledo Study for Healthy Aging were included. Muscle power was assessed with the5-repetition sit-to-stand test and participants were classified into different groups of relative power (ie, normalized to body mass) accordingto sex-specific tertiles and their inability to perform the test. Mean follow-up periods for hospitalization and all-cause mortality were 3.3 and6.3 years, respectively.Results: Compared to the high relative muscle power group, men with low (HR [95% CI] = 2.1 [1.2–3.6]) and women with very low andlow (HR [95% CI] = 4.7 [3.0–7.4] and 1.8 [1.2–2.7]) relative power had an increased age-adjusted risk of hospitalization. After adjustingfor several covariates (age, physical activity, body mass index education, depression, comorbidities, disability, and handgrip strength), theseeffects were attenuated (men and women with very low relative power: HR [95% CI] = 1.6 [0.9–2.9] and 2.8 [1.6–4.9]). The very low relativemuscle power group had also an increased all-cause mortality risk (age-adjusted) in both men and women (HR [95% CI] = 2.3 [1.4–3.9] and2.9 [1.6–5.3]). After adjusting for all the covariates, a significantly increased mortality risk was observed only in men (HR [95% CI] = 2.1[1.1–3.8]; women HR [95% CI] = 1.6 [0.8–3.2]), with very low levels of relative power.Conclusions: Relative muscle power was independently and negatively associated with mortality and hospitalization in older adults. Anaugmented all-cause mortality risk was noted in the lowest group of relative muscle power.

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