Effects of cannabis use on neural progenitors and neuronal differentiation in humans

  1. A. Delgado Sequera 1
  2. M. Hidalgo-Figueroa 1
  3. M. C. Durán-Ruiz 1
  4. V. Pérez
  5. A. Micó 1
  6. C. Carmen 1
  7. R. de la Torre
  8. P. Robledo
  9. E. Berrocoso 1
  1. 1 Universidad de Cádiz

    Universidad de Cádiz

    Cádiz, España

    ROR https://ror.org/04mxxkb11

32nd Congress of the European-College-of-Neuropsychopharmacology (ECNP)

Editorial: ELSEVIER

ISSN: 0924-977X

Año de publicación: 2019

Tipo: Aportación congreso

DOI: 10.1016/J.EURONEURO.2019.09.190 GOOGLE SCHOLAR lock_openAcceso abierto editor


Cannabis consumption is intimately linked to the early onset of psychotic episodes in patients predisposed to develop schizophrenia. There is much controversy in the current literature about the effects of Cannabis sativa and the absence of adequate tissue or cell models makes itdifficult to study the alterations produced by cannabis in the adult human brain. In the present work we use cells derived from human olfactory neuroepithelium to analyse the consequences at the cellular level of cannabis use. The olfactory neuroepithelium is a pseudostratified epitheliumpresent in adult mammals, comprising three primary layers: a basal layer, an intermediate region and an apical layer. The basal layer contains neural progenitors that give rise to olfactory neurons, which make it a good model to study cell proliferation and neuronal differentiation, including mor-pho functional alterations induced by cannabis use