Olfactory neuroepithelium cells derived from humans to study mental disorders

  1. M. Hidalgo Figueroa 1
  2. A. Delgado-Sequera 1
  3. M. C. Durán-Ruiz 1
  4. V. Perez
  5. J. A. Mico 1
  6. C. Castro 1
  7. R. de la Torre
  8. P. Robledo
  9. E. Berrocoso 1
  1. 1 Universidad de Cádiz

    Universidad de Cádiz

    Cádiz, España

    ROR https://ror.org/04mxxkb11

32nd Congress of the European-College-of-Neuropsychopharmacology (ECNP)

Publisher: ELSEVIER

ISSN: 0924-977X

Year of publication: 2019

Type: Conference paper

DOI: 10.1016/J.EURONEURO.2019.09.315 GOOGLE SCHOLAR lock_openOpen access editor


The study of mental disorders has been difficult due to the impossibility to obtain brain biopsies from alive patients. In order to study neuronal function in people suffering from mental illness, recent studies describe the use of differentiated neurons derived from iPSC-derivedfibroblasts from patients. Although this is an interesting cel- lular model, it has several limitations, including difficulty to reprogram these cells and the long time it requires. The olfactory neuroepithelium (ON) contains a neurogenic niche that gives rise to olfactory sensory neurons throughout life. Neuronal progenitors from this tissue are easily extracted from humans and can be propagated and differentiated into neurons under appropriate in vitro conditions. These char-acteristics make the ON a useful cellular model to study mental disorders, especially those with a neurodevelopmental origin, since alterations occurring during neural progenitor proliferation and differentiation can be studied in vitro. Patients suffering from schizophrenia (SZ) present alterations in neuronal morphology and function and may have a neurodevelopmental origin. Thus, cells from ON are useful to study those alterations. There is a link between cannabis use during adolescence and the early onset schizophrenia, in people with high vulnerability to develop this disease