Tumor mülleriano mixto maligno (carcinosarcoma heterólogo) de trompa uterina
- Natalia García Gómez 2
- Manuel Beltrán Ruiz-Henestrosa 1
- José María Báez Perea 1
- Susana García Gómez 3
- María José Añón Requena 1
- Pilar Cabello Torres 1
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1
Hospital Universitario Puerta del Mar
info
- 2 Facultad de Medicina. Universidad de Cádiz
- 3 Facultad de Medicina. Universidad Complutense. Madrid
ISSN: 1699-8855
Year of publication: 2005
Volume: 38
Issue: 2
Pages: 109-111
Type: Article
More publications in: Revista Española Patologia
Abstract
Background: Malignant mixed mullerian tumor is an uncommon neoplasm of the female genital tract. The Fallopian tube is most uncommon site. Patients and Methods: The reported case corresponds to a 66 year old woman with abdominal pain. A total hysterectomy with bilateral salpingo-oophorectomy was performed. Results: The neoplasm distended and distorted the left Fallopian tube. On cut section the tube was filled and expanded by a soft tumor with hemorrhagic areas. Microscopically it was composed of malignant epithelial and stromal elements with foci of cartilaginous and rhabdomyosarcomatous differentiation. Conclusions: Four theories have been put forward to explain the origins of the Fallopian tube carcinosarcomas. C-erbB-2 over-expression in both epithelial and mesenchymal components suggests a common carcinogenic mechanism for both components and supports the conversion-histogenesis hypothesis implicating a dominant role for epithelial component.