Fisiopatología de la HSAalteraciones en la funcionalidad vascular en un modelo animal de HSA y cambios en las células mononucleares de sangre periférica de pacientes

Laburpena

The legislative changes that have occurred in the European Union because of the appearance of the EU Directive 2014-24 on public procurement, have changed the paradigm in the cost control of public building construction, which goes from determining construction costs to costs throughout the life cycle of the building, as a parameter for evaluating public tenders. The main objective of the research is to design a methodology that allows the pre-dimensioning of costs of the entire life cycle of the building, starting at the previous stages of design and considering the costs of pre-construction, construction, use and end-of-life. Based on the structures given by professional standards such as UNE-EN-15643-4 and UNE-EN16627, and taking as a reference the data provided by measurements and budgets of existing buildings, and the Andalusian Construction Cost Database, it is proposed a construction information classification system, and a life cycle cost pre-dimensioning database. In addition, a calculation model is developed that allows a costs standardization in order to obtain the actual value of the investment cost. Life cycle costs are estimated for the building use periods of 40, 70 and 100 years. This methodology is applied to the case study of a secondary school in Andalusia, Spain. The results of 100 years study period distributes the costs (€ 3,892.14 / m2), 9% in the pre-construction stage, 32% in the construction stage, 58% in the use stage and 1% in the end-of-life stage, using a 1.5% discount rate. The taxation costs of the life cycle amount to 2% and the other expenses of the promoter to 4%. The proposed information structure and the calculation model allow simulations of different economic data and different construction elements, being useful for decision-making in the initial stages of building design.