Disfunción de la Corteza Temporo-Parietal y el Circuito de la Atención como Endofenotipo de la DepresiónTemporo-Parietal Cortex and Attention Circuit Dysfunction as Endophenotype of Depression

Abstract

Depression is one of the most prevalent mental disorder which generates great social, economic and human costs. Beyond, it presents a high comorbidity with other affective disorders and a high mortality rate (Paykel, Brugha & Fryeres, 2005). The familiar nature of the major depressive disorder (onwards, MDD) has been highlighted by several studies, and therefore, MDD has been conceptualized as a disorder originated by genetic components (Gershon et al., 1982; Sullivan, Neale & Kendler, 2000; Talati, Weissman & Hamilton, 2013) and its interaction with environmental factors (Bierut et al., 1999, Vázquez C. et al., 2010, Disner et al-. 2011). Therefore, individuals with a family history of depression (onwards, FH) are considered to manifest more likely depressive endophenotypes (Tatali et al., 2013).In general, MDD is considered as an affective disorder characterized by an altered emotional processing. Therefore, the abnormalities in the brain functioning underlying these processes associated to the FH status should represent reliable candidates for endophenotypes of depression...