Macular edema as a histological factor mediating color perception

  1. García-Palomeque J.C. 3
  2. García-lñiguez M. 1
  3. García-Gómez N. 3
  4. Molero-Chamizo A. 2
  5. Salido M. 3
  1. 1 Ophthalmology Service, Andalusian Health Service, Jerez, Spain
  2. 2 Psychobiology Area, University of Huelva, Spain
  3. 3 Histology Department, School of Medicine, Cádiz University, Spain
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Actas:
XXI CONGRESO DE LA SOCIEDAD ESPAÑOLA DE HISTOLOGÍA E INGENIERÍA TISULAR IX INTERNATIONAL CONGRESS OF HISTOLOGY AND TISSUE ENGINEERING VII CONGRESO IBEROAMERICANO DE HISTOLOGÍA

Año de publicación: 2022

Tipo: Aportación congreso

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Resumen

lntroduction: Macular edema is a clinical sign that is associated with various ophthalmological pathologies and that usually causes decreased vision or scotoma [1]. The morphology and location of the scotoma are helpful in locating ocular injury and its magnitude. However, the evaluation of perceived color is an undervalued clinical sign. The objective of this study is to explore the relationship between histological changes and the chromatic characteristics of the scotoma. The macular lesion can compromise the processing of color by the blue, green, and red eones, as well as the on/off activity of the ganglion cells, through a potential mechanism of ultrastructural modification of retina! histology. Thus, a macular edema can promete the formation of scotomas associated with a primary color. Methods: In this study we describe a series of clínica! cases of patients with macular edema. In oneof them, a macular edema was observed in the inferior temporal region, associated with scotomawith perception of blue color. In the other patients, an alteration in vision was detected, withoutassociated scotoma. The patient with scotoma was treated with intraocular glucocorticoid injectionafter the appearance of the blue scotoma.Results: A month after starting intraocular therapy, the macular edema remitted, and the bluishscotoma disappeared. Two months after pharmacological intervention, the edema reappeared, aswell as the bluish scotoma. Histological changes were observed vía coherence computed axialtomography (CAT) and eye fundus examination performed at this stage of the patient's evolution.Changes in the size of the retina were calculated, as well as the angle of refraction of light, usingSnell's Law. Discussion & conclusions: lt can be concluded that the visual perception of the blue tone in this patient may be due to an alteration in the trichromatic processing of color attributed to the functionality of the eones affected by the location of the edema [2,3].