lnvolvement of synovial activity in extraosseous endochondral ossification: H istopathological characteristics

  1. García-Palomeque J.C. 2
  2. Hens-Perez A. 3
  3. Molero-Chamizo A. 1
  4. Larran J. 2
  1. 1 Psychobiology Area, University of Huelva, Spain
  2. 2 Histology Department, School of Medicine, Cádiz University, Spain
  3. 3 Pathology Service, Andalusian Health Service, Puerto Real, Cádiz, Spain
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Actas:
XXI CONGRESO DE LA SOCIEDAD ESPAÑOLA DE HISTOLOGÍA E INGENIERÍA TISULAR IX INTERNATIONAL CONGRESS OF HISTOLOGY AND TISSUE ENGINEERING VII CONGRESO IBEROAMERICANO DE HISTOLOGÍA

Año de publicación: 2022

Tipo: Aportación congreso

GOOGLE SCHOLAR

Resumen

lntroduction: Endochondral ossification is linked to severa! pathological processes, and it has been shown to be the origin of primary lesions with benign characteristics in synovial locations, such as arthritic joints, tendon sheaths, and bursae. An inflammatory process seems to be related to endochondral ossification in the integrating histologic lesion characteristic of the aortic valve disease [1 ,2]. Chondral lesions outside the bone tissue are poorly understood. In this study we review severa! cases of benign chondral tumors with extraosseous lesions related to synovial mechanisms. The objective is to describe these tumors histologically in order to explore their etiopathogenesis and their possible relationship with degenerative aortic stenosis with osteochondral component. Methods: Seven cases of benign extraosseous tumors were analyzed. The inclusion criteria were the following: benign cartilaginous tumor, location in synovial tissues, and association with inflammatory processes. The histological study was performed by hematoxylin-eosin staining and the pathological diagnosis of the chondral lesion and its histological typing were performed by a specialist pathologist.Results: Samples from 7 patients showed cartilaginous histological lesions. The diagnostic characteristics of these patients are shown in Table 1. Histological findings revealed cartilaginous tissue with an endochondral ossification profile in the samples. Discussion and conclusions: In a series of 7 patients, we observed cartilage lesion in locations with synovial physiology. In all of them, inflammatory processes were evident, which could have triggered cell differentiation mechanisms towards cartilage tissue. These findings have clinical implications since these mechanisms could be pharmacologically modulated. In this vein, in degenerative aortic stenosis, two phases occur around the connective tissue. An initial phase of inflammation and calcification related to the accumulation of saturated fatty acids, and a secondphase of endochondral ossification. Our results suggest a parallelism between this pathology and the histological pathogenesis of the chondral lesion [3].