Maximal fat oxidation capacity and FatMax are related with body composition but not with triglyceridaemia in Type 2 Diabetes Mellitus patients

  1. Manuel Costilla
  2. Rafa Baturone-Servan
  3. Carlos Morillas-Cantos
  4. Alberto Morillas Cantos
  5. María Rebollo-Ramos
  6. Alberto Marín-Galindo
  7. Adrián Montes-de-Oca-García
  8. Jesús G. Ponce-González

Publisher: Instituto Politécnico de Setúbal – Escola Superior de Educação Centro de Investigação em Qualidade de Vida

ISBN: 978-989-35059-3-9

Year of publication: 2023

Pages: 33

Type: Conference paper


Maximal fat oxidation capacity (MFO) and the relative intensity of VO2max where it occurs (FatMax) are impaired in people with metabolic diseases as Type 2 Diabetes Mellitus (T2DM). Additionally, MFO and FatMax are related to body composition and blood substrate availability. Nevertheless, the association between body composition and blood substrate availability and the influence of triglyceridemia have been poorly studied in the T2DM population. A cross-sectional study was conducted on 99 T2DM patients (men=61). MFO and FatMax were assessed by indirect calorimetry with a gradual test with 15W increments every 3 minutes until RER achieved 1. On fasting condition, blood extraction was conducted and body mass (BM), lean mass (LM), muscle mass (MM) and fat mass (FM) were measured using a multifrequency bioimpedance following these considerations: i) to refrain from vigorous exercise 24h before, ii) to avoid alcoholic or energy drinks 24h before, iii) to be in a fasting state for 8h. Significant correlations were found between MFO and BM (p<0.001, r=0.485), FM (p<0.05, r=262), LM (p<0.001, r=0.518) and MM (p<0.001; r=0.515). Also, FatMax was associated with BM (p<0.005, r=0.291), fat percentage (p<0.05, r=0.209) and FM (p<0.005, r=0.285). Results showed that MFO and FatMax are correlated with body composition in T2DM patients. MFO is correlated with BM, FM, LM and MM but FatMax only correlates with BM and FM. This findings suggest that muscle, as a metabolically active organ, contributes to higher rates of fat oxidation but not modifies the FatMax point. Neither MFO nor FatMax were associated with trglyceridaemia.