Mortality and cardiovascular risk in vasculitis ANCA. Importance of hypertension and renal function. Experience from southern Spain

  1. M.A. Martin-Gómez 1
  2. A. Rodríguez Torres 2
  3. M. Espinosa Hernández 3
  4. M. Lopez Mendoza 4
  5. J.M. Sabio Sánchez 5
  6. M. Martin Armada 6
  7. I. Martin Suarez 7
  8. J.L. Callejas Rubio 8
  9. M.M. Castilla Castellano 9
  10. J.C. Anglada Pintado 10
  11. A.C. Barnosi Marín 11
  12. M.D. Martinez Esteban 12
  13. L. Castilla Guerra 13
  14. E. De Ramón Garrido 14
  1. 1 Nephrology Poniente Hospital, El Ejido, Almería
  2. 2 Nephrology Pediatrician Torrecardenas Hospital, Almería
  3. 3 Nephrology Reina Sofía Hospital, Córdoba
  4. 4 Nephrology Virgen del Rocío Hospital, Sevilla
  5. 5 Internal Medicine Autoimmune Unit, Virgen de las Nieves Hospital, Granada
  6. 6 Internal Medicine, Jaén Hospital Complex, Jaén
  7. 7 Internal Medicine, Juan Ramón Jiménez Hospital, Huelva
  8. 8 Internal Medicine, San Cecilio Clinic Hospital, Granada
  9. 9 Nephrology Costa del Sol Hospital, Marbella, Málaga
  10. 10 Internal Medicine, University Hospital of Jerez, Jerez, Cádiz
  11. 11 Internal Medicine, Torrecárdenas Hospital, Almería
  12. 12 Nephrology Universitary Regional Hospital of Málaga, Málaga
  13. 13 Internal Medicine, Virgen de Macarena Hospital, Sevilla
  14. 14 Internal Medicine, Andalussian Society of Autoimmune Diseases (AADEA), Spain
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Revista:
Hipertensión y riesgo vascular

ISSN: 1889-1837

Ano de publicación: 2024

Volume: 41

Número: 1

Páxinas: 5-16

Tipo: Artigo

DOI: 10.1016/J.HIPERT.2023.06.001 DIALNET GOOGLE SCHOLAR

Outras publicacións en: Hipertensión y riesgo vascular

Resumo

Background Cardiovascular disease (CVD) is one of the principal causes of death in antineutrophil cytoplasmic antibody-(ANCA)-associated vasculitis (AAV). Objectives To evaluate the mortality and it's causes and CVD and its vascular risk factors (VRFs) in AAV patients in Andalusia. Methods A multicenter cohort of 220 AAV patients followed-up from 1979 until June 2020 was studied in Andalussia, south of Spain. The information, including socio-demographic and clinical data was recorded retrospectively through chart review. Data was analysed using Chi2, ANOVA and Cox proportional hazards regresion as uni and multivariate test with a 95% confidence interval (CI). Results During a mean ± standard deviation follow-up of 96.79 ± 75.83 months, 51 patients died and 30 presented at least one CVE. Independent prognostic factors of mortality were age (HR 1.083, p=0.001) and baseline creatinine (HR 4.41, p=0.01). Independent prognostic factors of CVE were age [hazard ratio (HR) 1.042, p=0.005] and the presence of hypertension (HTN) six months after diagnosis (HR 4.641, p=0.01). HTN, diabetes and renal failure, all of these important VRFs, are more prevalent in AAV patients than it is described in matched general population. Conclusions Age and baseline renal function, but not CVEs, are predictors of mortality and age and early HTN are independent predictors for having a CVE. CVD screening in AAV patients is demanded.

Fonte de datos: Dialnet