Actividades aminopeptidasas en los ejes hipotálamo-hipófisis-hígado e hipotálamo-hipófisis-testículos:estudio del efecto de distintas dietas altas en grasa

Abstract

High fat diets are associated with a high risk of metabolic disorders, causing disorders such as overweight, insulin resistance, hypertension, liver steatosis, and reproductive dysfunction, among others. This work proposes that the intake of a diet enriched with extra virgin olive oil (EVOO) could act as a protective factor against metabolic and reproductive disorders, unlike a diet enriched in butter and cholesterol, whose intake would favor the appearance of such primary (liver and testis), secondary (pituitary) or tertiary (hypothalamus) endocrine disorders. It is proposed that different components of the EVOO would modulate enzyme systems, among them the Renin-Angiotensin System, enzymes involved in the regulation of oxidative stress, the control of food intake and blood glucose. The set of results mediated by modifications in peptidase activities indicates a protective effect of virgin olive oil compared to lipid sources rich in saturated fatty acids and cholesterol.