The early antidepressant-like effect of deep brain stimulation: Patterns of activity and their moduation by analgesics

  1. L. Perez-Caballero 1
  2. M. L. Soto-Montenegro 2
  3. M. Hidalgo-Figueroa 1
  4. M. Casquero-Veiga 2
  5. J. A. Mico 1
  6. M. Desco
  7. E. Berrocoso 1
  1. 1 Universidad de Cádiz
    info

    Universidad de Cádiz

    Cádiz, España

    ROR https://ror.org/04mxxkb11

  2. 2 Instituto de Investigación Sanitaria Gregorio Marañón
    info

    Instituto de Investigación Sanitaria Gregorio Marañón

    Madrid, España

Proceedings:
31st Congress of the European-College-of-Neuropsychopharmacology (ECNP)

Publisher: ELSEVIER

ISSN: 0924-977X

Year of publication: 2019

Type: Conference paper

DOI: 10.1016/J.EURONEURO.2018.11.560 GOOGLE SCHOLAR lock_openOpen access editor

Abstract

Deep Brain Stimulation (DBS) in the subgenual cingulate (Cg25) is an approach currently investigated to treat resistant major depressive disorder. The first clinical series have reported an initial antidepressant response followed by a worsening of the symptomatology. Both clinical and preclinical findings showed that the implantation of the stimulation electrode causes an initial antidepressant effect, which seems to be mediated by a local inflammation and is abolished by treatment with NSAIDs (nonsteroidal anti-inflammatory drugs)