The early antidepressant-like effect of deep brain stimulation: Patterns of activity and their moduation by analgesics
- L. Perez-Caballero 1
- M. L. Soto-Montenegro 2
- M. Hidalgo-Figueroa 1
- M. Casquero-Veiga 2
- J. A. Mico 1
- M. Desco
- E. Berrocoso 1
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1
Universidad de Cádiz
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2
Instituto de Investigación Sanitaria Gregorio Marañón
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Instituto de Investigación Sanitaria Gregorio Marañón
Madrid, España
Editorial: ELSEVIER
ISSN: 0924-977X
Ano de publicación: 2019
Tipo: Achega congreso
Resumo
Deep Brain Stimulation (DBS) in the subgenual cingulate (Cg25) is an approach currently investigated to treat resistant major depressive disorder. The first clinical series have reported an initial antidepressant response followed by a worsening of the symptomatology. Both clinical and preclinical findings showed that the implantation of the stimulation electrode causes an initial antidepressant effect, which seems to be mediated by a local inflammation and is abolished by treatment with NSAIDs (nonsteroidal anti-inflammatory drugs)